Buccal Drug Delivery System
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چکیده
The buccal mucosa lines the inner cheek, and buccal formulations are placed in the mouth between the upper gingivae (gums) and cheek to treat local and systemic conditions. The buccal route provides one of the potential route for typically large, hydrophilic and unstable proteins, oligonucleotides and polysaccharides, as well as conventional small drug molecules. The oral cavity has been used as a site for local and systemic drug delivery.
منابع مشابه
Drug Delivery Based on Buccal Adhesive Systems - a Review
Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity.The objective of this article is to review buccal drug delivery by discussing the structure and environment of the oral mucosa and highlighting the mechanisms of drug permeation and methodology in evaluating buccal formulations. This review also highlights a brief descri...
متن کاملA Comprehensive Review on Buccal Drug Delivery System
Bioadhesion can be defined as a phenomenon of interfacial molecular attractive forces in the midst of the surfaces of biological substrate and the natural or synthetic polymers, which allows the polymer to adhere to biological surface for an extended period of time. Within the oral mucosal cavity, the buccal region offers an adorable route of administration for systemic drug delivery. Among the...
متن کاملبررسی تأثیر نوع و مقدار پلیمر بر قدرت مخاط چسبی و سرعت آزادسازی دارو از فیلم های مخاط چسب داخل گونه ای دیکلوفناک سدیم
Background and purpose: Buccal delivery of drug provides an attractive alternative to the oral route of drug administration and a convenient route of administration for both systemic and local drug delivery. Absorption of therapeutic agents from the oral cavity provides a direct entry for such agents into the systemic circulation, thereby avoiding first-pass metabolism and gastrointestinal d...
متن کاملNovel Aproaches - Mucoadhesive Buccal Drug Delivery System
Among novel drug delivery systems, Buccal mucoadhesive systems have attracted great attention in recent years due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. Mucoadhesion may be defined as the process where polymers attach to biological substrate or a synthetic or natural macromolecule, to mucus or an epithelial surface. Buccal mucoadhes...
متن کاملIn-vitro and In-vivo Evaluation of Novel Mucoadhesive Buccal Drug Delivery Systems-a Review
The buccal mucosa is one of the administration sites that might provide an alternative for peroral administration. Mucoadhesive buccal drug delivery systems is one of the most important novel drug delivery systems with its various advantages and it has a lot of potential in formulating dosage forms for various chronic diseases. The delivery of drugs through the buccal mucosa has attracted much ...
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